Drug Information

Drug General Information
Drug ID
D0D3QA
Former ID
DNC006337
Drug Name
4-(isoquinolin-5-yl)-N-m-tolylphthalazin-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527948]
Structure
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2D MOL

3D MOL
Formula
C24H18N4
Canonical SMILES
CC1=CC(=CC=C1)NC2=NN=C(C3=CC=CC=C32)C4=CC=CC5=C4C=CN=C5
InChI
1S/C24H18N4/c1-16-6-4-8-18(14-16)26-24-22-10-3-2-9-21(22)23(27-28-24)20-11-5-7-17-15-25-13-12-19(17)20/h2-15H,1H3,(H,26,28)
InChIKey
KGVVWWXTGNZBAX-UHFFFAOYSA-N
PubChem Compound ID
44409436
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 2 Target Info Inhibitor [527948]
mRNA of VEGFR1 Target Info Inhibitor [527948]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
S1P3 pathway
VEGFR1 specific signals
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
WikiPathways Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
Angiogenesis
References
Ref 527948Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. Epub 2005 Dec 28.Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II.
Ref 527948Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. Epub 2005 Dec 28.Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II.

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