Drug General Information
Drug ID	D0D3ID
Former ID	DNC004037
Drug Name	GAMMA-AMINO-BUTANOIC ACID
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528408]
Structure		Download 2D MOL 3D MOL
Formula	C4H9NO2
Canonical SMILES	C(CC(=O)O)CN
InChI	1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChIKey	BTCSSZJGUNDROE-UHFFFAOYSA-N
PubChem Compound ID	119
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528408]
	Gamma-aminobutyric acid B receptor	Target Info	Inhibitor	[528071]
	GABA transporter-3	Target Info	Inhibitor	[533538]
	Gamma-aminobutyric-acid receptor alpha-2 subunit	Target Info	Inhibitor	[533580]
	Gamma-aminobutyric-acid receptor alpha-3 subunit	Target Info	Inhibitor	[533580]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528408]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[528408]
	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528408]
	Gamma-aminobutyric-acid receptor alpha-5 subunit	Target Info	Inhibitor	[533580]
	Sodium- and chloride-dependent GABA transporter 1	Target Info	Inhibitor	[527271]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04024:cAMP signaling pathway
	Estrogen signaling pathway
	Morphine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addictionhsa04727:GABAergic synapse
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-1296041:Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP501:GPCRs, Class C Metabotropic glutamate, pheromone
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signalingWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP706:SIDS Susceptibility Pathways
	Iron uptake and transportWP727:Monoamine Transport
	NRF2 pathway
References
Ref 528408	J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 527271	J Med Chem. 2004 Nov 4;47(23):5620-9.Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling.
Ref 528071	J Med Chem. 1991 Aug;34(8):2557-60.3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies.
Ref 528408	J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 533538	J Med Chem. 1981 Jul;24(7):788-94.Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro.
Ref 533580	J Med Chem. 1980 Jun;23(6):702-4.New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide.

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