Drug General Information
Drug ID	D0D2WC
Former ID	DNC005030
Drug Name	5-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527210]
Structure		Download 2D MOL 3D MOL
Formula	C7H14N2
Canonical SMILES	CCC1CC(C(=N1)N)C
InChI	1S/C7H14N2/c1-3-6-4-5(2)7(8)9-6/h5-6H,3-4H2,1-2H3,(H2,8,9)
InChIKey	WPWKHPKZOKESJR-UHFFFAOYSA-N
PubChem Compound ID	17892465
Target and Pathway
Target(s)	Nitric-oxide synthase, endothelial	Target Info	Inhibitor	[527210]
	Nitric-oxide synthase, brain	Target Info	Inhibitor	[527210]
BioCyc Pathway	Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	cGMP-PKG signaling pathway
	HIF-1 signaling pathway
	Sphingolipid signaling pathway
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Platelet activation
	Estrogen signaling pathway
	Oxytocin signaling pathwayhsa00330:Arginine and proline metabolism
	Phagosome
	Circadian entrainment
	Long-term depression
	Salivary secretion
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
NetPath Pathway	Wnt Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
PANTHER Pathway	Angiogenesis
	Endothelin signaling pathway
	Interleukin signaling pathway
	PI3 kinase pathway
	VEGF signaling pathwayP06959:CCKR signaling map ST
Pathway Interaction Database	Plasma membrane estrogen receptor signaling
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Angiopoietin receptor Tie2-mediated signaling
	Thromboxane A2 receptor signaling
	SHP2 signaling
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
PathWhiz Pathway	Arginine and Proline Metabolism
Reactome	ROS production in response to bacteria
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	eNOS activation
	Nitric oxide stimulates guanylate cyclase
	VEGFR2 mediated vascular permeabilityR-HSA-1222556:ROS production in response to bacteria
WikiPathways	ACE Inhibitor Pathway
	EGF/EGFR Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	JAK/STAT
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	Endothelin Pathways
	Leptin signaling pathway
	Effects of Nitric Oxide
	Metabolism of nitric oxide
	AngiogenesisWP727:Monoamine Transport
	Amyotrophic lateral sclerosis (ALS)
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Alzheimers Disease
	Serotonin Transporter Activity
References
Ref 527210	Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44.Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
Ref 527210	Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44.Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.

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