Drug Information

Drug General Information
Drug ID
D0D2UA
Former ID
DIB000835
Drug Name
2-NAP
Synonyms
N-(2-Naphthylsulfonyl)-L-aspartic acid 2-phenylethylamide sodium salt
Drug Type
Small molecular drug
Indication Gastrointestinal disease [ICD10:K00-K93] Investigative [528483]
Structure
Download
2D MOL

3D MOL
Formula
C22H22N2O5S
Canonical SMILES
C1=CC=C(C=C1)CCNC(=O)C(CC(=O)O)NS(=O)(=O)C2=CC3=CC=CC=C<br />3C=C2
InChI
1S/C22H22N2O5S/c25-21(26)15-20(22(27)23-13-12-16-6-2-1-3-7-16)24-30(28,29)19-11-10-17-8-4-5-9-18(17)14-19/h1-11,14,20,24H,12-13,15H2,(H,23,27)(H,25,26)/t20-/m0/s1
InChIKey
VMYREBYTVVSDDK-FQEVSTJZSA-N
CAS Number
CAS 141577-40-4
PubChem Compound ID
9867157
PubChem Substance ID
14831995, 45289423, 47805480, 48404414, 77380095, 103213863, 135261722
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Antagonist [528483]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528483Unexpected relationship between plasma protein binding and the pharmacodynamics of 2-NAP, a CCK1-receptor antagonist. Br J Clin Pharmacol. 2007 May;63(5):618-22. Epub 2006 Oct 17.
Ref 528483Unexpected relationship between plasma protein binding and the pharmacodynamics of 2-NAP, a CCK1-receptor antagonist. Br J Clin Pharmacol. 2007 May;63(5):618-22. Epub 2006 Oct 17.

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