Drug Information

Drug General Information
Drug ID
D0D1SG
Former ID
DIB011425
Drug Name
Prednisolone
Synonyms
Nanocort; Prednisolone (injectable liposome formulation, rheumatoid arthritis); Prednisolone (injectable liposome formulation, rheumatoid arthritis), Enceladus; Prednisolone (injectable liposome formulation, rheumatoid arthritis), Galapagos
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Approved [551871]
Multiple scierosis [ICD9: 340; ICD10:G35] Phase 3 [525302], [539891]
Therapeutic Class
Anticancer Agents
Company
Schering Corp Sub Schering Plough Corp
Structure
Download
2D MOL

3D MOL
Formula
C21H28O5
InChI
InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey
OIGNJSKKLXVSLS-VWUMJDOOSA-N
PubChem Compound ID
5755
PubChem Substance ID
9573, 74674, 75254, 7847538, 7980377, 8153532, 10321429, 11466302, 11467422, 11486103, 12012573, 12146616, 14876794, 14876795, 24870351, 24898079, 24898725, 26697414, 29224791, 46504847, 46519223, 47500929, 47647896, 47945232, 48244811, 48414366, 48416460, 49698415, 49857644, 50085972, 50124371, 50643467, 53790825, 56311149, 56312886, 56313992, 56463372, 57288815, 57650843, 81093218, 85300842, 85788424, 87574796, 92125114, 92309181, 92710510, 93576750, 103189031, 103913923, 104169971
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Modulator [525912]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 525302ClinicalTrials.gov (NCT02534896) To Evaluate The Efficacy And Safety Of Intravenous Pegylated Liposomal Prednisolone Sodium Phosphate (Nanocort) Compared With Intramuscular Injection Of Methylprednisolone Acetate In Subjects With Active Rheumatoid Arthritis.
Ref 539891(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2866).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 525912Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice. Laryngoscope. 2000 Nov;110(11):1902-6.

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