Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D1BC
|
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| Former ID |
DNC000922
|
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| Drug Name |
Melanocortin-4 Receptor antagonist
|
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| Drug Type |
Small molecular drug
|
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| Indication | Anorexia nervosa cachexia [ICD9: 307.1, 799.4; ICD10:F50.0-F50.1] | Investigative | [1] | ||
| Company |
Santhera
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H34O3
|
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| Canonical SMILES |
COC(=O)CCCCCCCCCCCCCCCO
|
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| InChI |
1S/C17H34O3/c1-20-17(19)15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18/h18H,2-16H2,1H3
|
||||
| InChIKey |
AOTMRIXFFOGWDT-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Melanocortin-4 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Pathway Interaction Database | Syndecan-3-mediated signaling events | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774 | ||||
| REF 2 | Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. | ||||
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