Drug Information

Drug General Information
Drug ID
D0D0TQ
Former ID
DIB000494
Drug Name
AKN-028
Synonyms
Flt3 tyrosine kinase inhibitor (AML), Akinion/Swedish Orphan Biovitrum/Karolinska
Drug Type
Small molecular drug
Indication Acute myeloid leukemia [ICD9: 205; ICD10:C92.0] Investigative [542885]
Company
Swedish Orphan Biovitrum AB
Structure
Download
2D MOL

3D MOL
Formula
C17H14N6
InChI
InChI=1S/C17H14N6/c18-16-17(22-13-1-2-14-12(9-13)5-8-20-14)23-15(10-21-16)11-3-6-19-7-4-11/h1-10,20H,(H2,18,21)(H,22,23)
InChIKey
JLRIJKVMMZEKDF-UHFFFAOYSA-N
PubChem Compound ID
44177328
PubChem Substance ID
85166348, 89939451, 138433279, 172650775, 198980044, 227832470, 245195041, 249565652
Target and Pathway
Target(s) FL cytokine receptor Target Info Inhibitor [543494]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
References
Ref 542885(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7969).
Ref 543494(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1807).

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