Drug General Information |
Drug ID |
D0CY1B
|
Former ID |
DCL000010
|
Drug Name |
CYC116
|
Drug Type |
Small molecular drug
|
Indication |
Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]
|
Phase 1 |
[1]
|
Therapeutic Class |
Anticancer Agents
|
Company |
Cyclacel Limited
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C18H20N6OS
|
Canonical SMILES |
CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4
|
InChI |
1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23)
|
InChIKey |
GPSZYOIFQZPWEJ-UHFFFAOYSA-N
|
PubChem Compound ID |
|
PubChem Substance ID |
11618518, 16832086, 24424536, 43014321, 46393965, 50521546, 99436925, 103652037, 103904403, 104120139, 114518369, 124757050, 125163854, 125329932, 125650062, 131480715, 134339467, 135685404, 135685405, 135685424, 136367344, 136367981, 136920315, 137276048, 141791974, 144115863, 152037316, 152258254, 152344039, 160647090, 162011811, 162037480, 162202552, 164194001, 170481285, 174561022, 180190851, 185965274, 188899569, 223653845, 223705256, 223964817, 228221334, 246870915, 249814521, 251963051, 252215210, 252451655, 252543304
|
Target and Pathway |
Target(s) |
Aurora kinase B |
Target Info |
Inhibitor |
[2]
|
Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[2]
|
Aurora kinase A |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
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Ras signaling pathway
|
Rap1 signaling pathway
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Cytokine-cytokine receptor interaction
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Endocytosis
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Focal adhesion
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Proteoglycans in cancerhsa04114:Oocyte meiosis
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NetPath Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
|
VEGF signaling pathway
|
Pathway Interaction Database
|
Aurora B signaling
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Signaling by Aurora kinases
|
Aurora C signaling
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FOXM1 transcription factor network
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Aurora A signalinghif2pathway:HIF-2-alpha transcription factor network
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Beta3 integrin cell surface interactions
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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VEGF and VEGFR signaling network
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Integrins in angiogenesis
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Signaling events mediated by VEGFR1 and VEGFR2
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Notch-mediated HES/HEY networkaurora_b_pathway:Aurora B signaling
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Integrin-linked kinase signaling
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PLK1 signaling events
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Aurora A signaling
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Reactome
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APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
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Separation of Sister Chromatids
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Resolution of Sister Chromatid Cohesion
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RHO GTPases Activate Formins
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Mitotic PrometaphaseR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerization
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Integrin cell surface interactions
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EPHA-mediated growth cone collapse
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VEGFA-VEGFR2 Pathway
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VEGFR2 mediated cell proliferationR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
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Regulation of PLK1 Activity at G2/M Transition
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WikiPathways
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Mitotic Metaphase and Anaphase
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Mitotic Prometaphase
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Regulation of Microtubule Cytoskeleton
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in epithelium - TarBase
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APC/C-mediated degradation of cell cycle proteinsWP306:Focal Adhesion
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Nifedipine Activity
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Cardiac Progenitor Differentiation
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Signaling by VEGF
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AngiogenesisWP437:EGF/EGFR Signaling Pathway
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JAK/STAT
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Gastric Cancer Network 1
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Integrated Breast Cancer Pathway
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APC/C-mediated degradation of cell cycle proteins
|
References |
REF 1 | ClinicalTrials.gov (NCT00560716) A Phase I Pharmacologic Study of CYC116, an Oral Aurora Kinase Inhibitor, in Patients With Advanced Solid Tumors. U.S. National Institutes of Health. |
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REF 2 | Clinical pipeline report, company report or official report of Cyclacel. |