Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0CB8W
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| Former ID |
DIB010876
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| Drug Name |
DE-081
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| Synonyms |
Apafant (ophthalmic formulation), Santen
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| Drug Type |
Small molecular drug
|
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| Indication | Conjunctivitis [ICD9: 372; ICD10:H10] | Discontinued in Phase 2 | [1] | ||
| Company |
Santen Pharmaceutical Co Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C22H22ClN5O2S
|
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| Canonical SMILES |
Cc1nnc2CN=C(c3ccccc3Cl)c4cc(CCC(=O)N5CCOCC5)sc4n12
|
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| InChI |
1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
|
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| InChIKey |
JGPJQFOROWSRRS-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000113) | ||||
| REF 2 | J Pharmacol Toxicol Methods. 1996 Sep;36(1):53-62.Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method. | ||||
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