Drug General Information
Drug ID	D0C9JJ
Former ID	DNCL002405
Drug Name	AR-12
Drug Type	Small molecular drug
Indication	Lymphoma [ICD9: 202.8, 208.9; ICD10:C81-C86]		Phase 1	[522785], [542919]
Structure		Download 2D MOL 3D MOL
Formula	C26H19F3N4O
InChIKey	YULUCECVQOCQFQ-UHFFFAOYSA-N
PubChem Compound ID	10027278
PubChem Substance ID	15008861, 22455284, 44144352, 77529760, 99436984, 124757004, 124966544, 125163809, 125335329, 131480760, 134222632, 134964418, 136367304, 136367847, 137248109, 137750678, 143499298, 144116327, 152234784, 152258252, 152344384, 160647088, 162011464, 162037439, 162205107, 163893414, 164159505, 172131582, 172650377, 174006452, 174530327, 174530328, 180096554, 186014822, 198945474, 223704779, 226877051, 242059900, 247295286, 249565685, 249871551, 252215975, 252438951
Target and Pathway
Target(s)	3-phosphoinositide dependent protein kinase-1	Target Info	Modulator	[1572591]
KEGG Pathway	PPAR signaling pathway
	FoxO signaling pathway
	Sphingolipid signaling pathway
	mTOR signaling pathway
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Focal adhesion
	T cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	Neurotrophin signaling pathway
	Insulin signaling pathway
	Thyroid hormone signaling pathway
	Aldosterone-regulated sodium reabsorption
	Toxoplasmosis
	Hepatitis C
	Proteoglycans in cancer
	Endometrial cancer
	Prostate cancer
	Non-small cell lung cancer
	Choline metabolism in cancer
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Insulin/IGF pathway-protein kinase B signaling cascade
	Interleukin signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	p53 pathway
	Ras Pathway
	p53 pathway feedback loops 2
	CCKR signaling map ST
Pathway Interaction Database	BCR signaling pathway
	Insulin Pathway
	TCR signaling in na&#xef
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	TCR signaling in na&#xef
	FAS (CD95) signaling pathway
	mTOR signaling pathway
	CXCR4-mediated signaling events
	IGF1 pathway
	Class I PI3K signaling events
	ErbB1 downstream signaling
	IL8- and CXCR2-mediated signaling events
	CXCR3-mediated signaling events
	VEGFR1 specific signals
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	Signaling events mediated by VEGFR1 and VEGFR2
	Class I PI3K signaling events mediated by Akt
	IL8- and CXCR1-mediated signaling events
	Trk receptor signaling mediated by PI3K and PLC-gamma
	FGF signaling pathway
	TGF-beta receptor signaling
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
	Insulin Signalling
Reactome	GPVI-mediated activation cascade
	PIP3 activates AKT signaling
	Activation of AKT2
	Role of LAT2/NTAL/LAB on calcium mobilization
	FCERI mediated NF-kB activation
	Integrin alphaIIb beta3 signaling
	CD28 dependent PI3K/Akt signaling
	CTLA4 inhibitory signaling
	G beta:gamma signalling through PI3Kgamma
	VEGFR2 mediated vascular permeability
	VEGFR2 mediated cell proliferation
	CLEC7A (Dectin-1) signaling
	RHO GTPases activate PKNs
	Constitutive Signaling by AKT1 E17K in Cancer
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	TCR Signaling Pathway
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	Focal Adhesion
	Cardiac Hypertrophic Response
	Fc epsilon receptor (FCERI) signaling
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	PIP3 activates AKT signaling
	BDNF signaling pathway
	Interleukin-11 Signaling Pathway
	B Cell Receptor Signaling Pathway
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	TCR signaling
	Signaling by Insulin receptor
	Integrin-mediated Cell Adhesion
	GPVI-mediated activation cascade
	GPCR downstream signaling
	Costimulation by the CD28 family
	MicroRNAs in cardiomyocyte hypertrophy
References
Ref 522785	ClinicalTrials.gov (NCT00978523) Study of AR-12 (2-Amino-N-[4-[5-(2 Phenanthrenyl)-3-(Trifluoromethyl)-1H-pyrazol-1-yl] Phenyl]-Acetamide) in Adult Patients With Advanced or Recurrent Solid Tumors orLymphoma. U.S. National Institutes of Health.
Ref 542919	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8005).
Ref 1572591	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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