Drug General Information
Drug ID	D0C9DC
Former ID	DNC004983
Drug Name	SK&F-64139
Synonyms	SK-64139
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528403]
Structure		Download 2D MOL 3D MOL
Formula	C9H9Cl2N
Canonical SMILES	C1CNCC2=C1C=CC(=C2Cl)Cl.Cl
InChI	1S/C9H9Cl2N.ClH/c10-8-2-1-6-3-4-12-5-7(6)9(8)11;/h1-2,12H,3-5H2;1H
InChIKey	MPGYNUDLCXDURR-UHFFFAOYSA-N
PubChem Compound ID	123920
Target and Pathway
Target(s)	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[528403]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[528403]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[528403]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (i) signalling events
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	GPCR downstream signaling
References
Ref 528403	J Med Chem. 2006 Sep 7;49(18):5424-33.Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamineN-methyltransferase.
Ref 528403	J Med Chem. 2006 Sep 7;49(18):5424-33.Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamineN-methyltransferase.

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