Drug Information
Drug General Information | |||||
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Drug ID |
D0C7LF
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Former ID |
DIB003694
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Drug Name |
DACOPAFANT
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Synonyms |
RP-55778; Dacopafant < Rec INN >; (+)-3(R)-(3-Pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carboxamide
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Drug Type |
Small molecular drug
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Indication | Septic shock [ICD9: 785.52; ICD10:A41.9] | Discontinued in Phase 1 | [544523] | ||
Structure |
Download2D MOL |
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Formula |
C12H11N3OS
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Canonical SMILES |
NC(=O)c1ccn2C(SCc12)c3cccnc3
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InChI |
1S/C12H11N3OS/c13-11(16)9-3-5-15-10(9)7-17-12(15)8-2-1-4-14-6-8/h1-6,12H,7H2,(H2,13,16)
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InChIKey |
ARFOASMERCHFBY-UHFFFAOYSA-N
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CAS Number |
CAS 125372-33-0
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [531635], [532945] | |
NetPath Pathway | IL5 Signaling Pathway | ||||
Leptin Signaling Pathway | |||||
References | |||||
Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
Ref 532945 | RP 55778, a PAF receptor antagonist, prevents and reverses LPS-induced hemoconcentration and TNF release. J Lipid Mediat. 1989 Nov-Dec;1(6):349-60. |
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