Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0C6QQ
|
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| Former ID |
DIB016758
|
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| Drug Name |
Besipirdine
|
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| Synonyms |
Besipirdine hydrochloride; HP-749; P-7480; P86-7480
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] | Phase 3 | [1] | ||
| Company |
Hoechst Marion Roussel Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C16H17N3
|
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| Canonical SMILES |
n1(ccc2c1cccc2)N(c1ccncc1)CCC
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Alpha-1A adrenergic receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| AMPK signaling pathway | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Salivary secretion | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Endothelin Pathways | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | Clinical pipeline report, company report or official report of UroGene. | ||||
| REF 2 | Alpha-Adrenergic activity and cardiovascular effects of besipirdine HCl (HP 749) and metabolite P7480 in vitro and in the conscious rat and dog. J Pharmacol Exp Ther. 1997 Apr;281(1):337-46. | ||||
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