Drug General Information
Drug ID
D0C3VI
Former ID
DNC003709
Drug Name
PD-167341
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525605]
Structure
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2D MOL

3D MOL

Formula
C33H46N4O5
Canonical SMILES
CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)OC(=O)C2=CC=CC=C2)C(=O)NC<br />(C)(C)C)NC(=O)N3CCCCCC3
InChI
1S/C33H46N4O5/c1-23(2)21-27(35-32(41)37-19-11-6-7-12-20-37)29(38)34-28(30(39)36-33(3,4)5)22-24-15-17-26(18-16-24)42-31(40)25-13-9-8-10-14-25/h8-10,13-18,23,27-28H,6-7,11-12,19-22H2,1-5H3,(H,34,38)(H,35,41)(H,36,39)/t27-,28-/m0/s1
InChIKey
RASCVEWVRJPMSU-NSOVKSMOSA-N
PubChem Compound ID
Target and Pathway
Target(s) Voltage-dependent N-type calcium channel Target Info Inhibitor [525605]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signaling
Reactome Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways Calcium Regulation in the Cardiac Cell
Synaptic Vesicle Pathway
References
Ref 525605J Med Chem. 1999 Oct 7;42(20):4239-49.Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties.
Ref 525605J Med Chem. 1999 Oct 7;42(20):4239-49.Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties.

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