Drug Information

Drug General Information
Drug ID
D0C2NK
Former ID
DIB020562
Drug Name
norfluoxetine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539317]
Structure
Download
2D MOL
Formula
C16H16F3NO
InChI
InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2
InChIKey
WIQRCHMSJFFONW-UHFFFAOYSA-N
PubChem Compound ID
4541
PubChem Substance ID
515992, 841245, 3249471, 4712768, 8152798, 14849332, 29223632, 50066100, 50707944, 57322322, 85209721, 92729852, 99443277, 103131848, 103556000, 104306700, 117505046, 125607181, 125812945, 126665903, 129587205, 135062212, 135371955, 135650734, 137016413, 141566791, 152050510, 160967894, 162919696, 163640919, 179293685, 184565588, 184605154, 223682774, 223809731, 225228000, 226980400, 249897421, 252236770, 252355234
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Antagonist [525929]
5-hydroxytryptamine 2A receptor Target Info Antagonist [525929]
5-hydroxytryptamine 2C receptor Target Info Antagonist [525929]
Kv3.1 Target Info Inhibitor (gating inhibitor) [526135]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539317(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 208).
Ref 525929Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41.
Ref 526135Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1. Neuropharmacology. 2001 Sep;41(4):443-53.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.