| Drug General Information |
| Drug ID |
D0C2GE
|
| Former ID |
DIB019613
|
| Drug Name |
compound 8h
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C25H26ClN5O
|
| InChI |
InChI=1S/C25H26ClN5O/c1-2-31-13-9-18(10-14-31)29-19-7-8-21-20(15-19)23(25(32)30-21)22(24-27-11-12-28-24)16-3-5-17(26)6-4-16/h3-8,11-12,15,18,29H,2,9-10,13-14H2,1H3,(H,27,28)(H,30,32)
|
| InChIKey |
XHCPCYVQXFHJAU-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
FL cytokine receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Vascular endothelial growth factor receptor 3 |
Target Info |
Inhibitor |
[1]
|
| Beta platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
| Basic fibroblast growth factor receptor 1 |
Target Info |
Inhibitor |
[1]
|
| ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
Target Info |
Inhibitor |
[1]
|
| mitogen-activated protein kinase kinase kinase kinase 3 |
Target Info |
Inhibitor |
[1]
|
| Alpha platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
| Mast/stem cell growth factor receptor |
Target Info |
Inhibitor |
[1]
|
| Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[1]
|
| mRNA of VEGFR1 |
Target Info |
Inhibitor |
[1]
|
| Proto-oncogene tyrosine-protein kinase SRC |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Cytokine-cytokine receptor interaction
|
|
Hematopoietic cell lineage
|
|
Pathways in cancer
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|
Transcriptional misregulation in cancer
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|
Acute myeloid leukemia
|
|
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
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Rap1 signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
Focal adhesionhsa04010:MAPK signaling pathway
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|
Ras signaling pathway
|
|
Calcium signaling pathway
|
|
Focal adhesion
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|
Gap junction
|
|
Regulation of actin cytoskeleton
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|
HTLV-I infection
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MicroRNAs in cancer
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Glioma
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Prostate cancer
|
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Melanoma
|
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Central carbon metabolism in cancer
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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Adherens junction
|
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Signaling pathways regulating pluripotency of stem cells
|
|
Proteoglycans in cancer
|
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Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
|
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Endocytosis
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Choline metabolism in cancerhsa04014:Ras signaling pathway
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Melanogenesis
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VEGF signaling pathway
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Proteoglycans in cancerhsa04014:Ras signaling pathway
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HIF-1 signaling pathway
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Rheumatoid arthritishsa04012:ErbB signaling pathway
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Chemokine signaling pathway
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Tight junction
|
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Platelet activation
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GABAergic synapse
|
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
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Estrogen signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Bacterial invasion of epithelial cells
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Tuberculosis
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Hepatitis B
|
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Viral carcinogenesis
|
|
NetPath Pathway
|
TNFalpha Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_15:IL3 Signaling Pathway
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IL4 Signaling Pathway
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KitReceptor Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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PDGF signaling pathwayP00005:Angiogenesis
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FGF signaling pathwayP00005:Angiogenesis
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VEGF signaling pathwayP00005:Angiogenesis
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Cadherin signaling pathway
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Integrin signalling pathway
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Parkinson disease
|
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CCKR signaling map ST
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|
Pathway Interaction Database
|
VEGF and VEGFR signaling network
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VEGFR3 signaling in lymphatic endotheliumptp1bpathway:Signaling events mediated by PTP1B
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Beta3 integrin cell surface interactions
|
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S1P3 pathway
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Nectin adhesion pathway
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
|
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
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PDGFR-beta signaling pathway
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Validated targets of C-MYC transcriptional repression
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PDGF receptor signaling networkglypican_1pathway:Glypican 1 network
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Syndecan-4-mediated signaling events
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N-cadherin signaling events
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FGF signaling pathwayatf2_pathway:ATF-2 transcription factor network
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PDGFR-alpha signaling pathway
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PDGF receptor signaling networkcmyb_pathway:C-MYB transcription factor network
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Signaling events mediated by Stem cell factor receptor (c-Kit)hif2pathway:HIF-2-alpha transcription factor network
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Integrins in angiogenesis
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Signaling events mediated by VEGFR1 and VEGFR2
|
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Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
|
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HIF-2-alpha transcription factor network
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2endothelinpathway:Endothelins
|
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Signaling events mediated by PRL
|
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LPA receptor mediated events
|
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Atypical NF-kappaB pathway
|
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Glypican 1 network
|
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Plasma membrane estrogen receptor signaling
|
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events mediated by PTP1B
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EPHB forward signaling
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Regulation of p38-alpha and p38-beta
|
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CDC42 signaling events
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Signaling events regulated by Ret tyrosine kinase
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Arf6 signaling events
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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Netrin-mediated signaling events
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Alpha9 beta1 integrin signaling events
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CXCR4-mediated signaling events
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EGF receptor (ErbB1) signaling pathway
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Class I PI3K signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
|
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Regulation of Androgen receptor activity
|
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E-cadherin signaling in the nascent adherens junction
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amb2 Integrin signaling
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ErbB1 downstream signaling
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ErbB2/ErbB3 signaling events
|
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EPHA forward signaling
|
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E-cadherin signaling in keratinocytes
|
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Nongenotropic Androgen signaling
|
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Internalization of ErbB1
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CXCR3-mediated signaling events
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Syndecan-2-mediated signaling events
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Class I PI3K signaling events mediated by Akt
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Syndecan-3-mediated signaling events
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Ephrin B reverse signaling
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Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
EPHA2 forward signaling
|
|
Alpha-synuclein signaling
|
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FGF signaling pathway
|
|
Alpha4 beta1 integrin signaling events
|
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Signaling events mediated by focal adhesion kinase
|
|
Reactome
|
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-1257604:PIP3 activates AKT signaling
|
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Constitutive Signaling by Aberrant PI3K in Cancer
|
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RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
|
|
Regulation of KIT signaling
|
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RAF/MAP kinase cascadeR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
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VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
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VEGFA-VEGFR2 Pathway
|
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VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
WikiPathways
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Signaling by VEGFWP51:Regulation of Actin Cytoskeleton
|
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MAPK Signaling Pathway
|
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Osteoblast Signaling
|
|
Focal Adhesion
|
|
PIP3 activates AKT signaling
|
|
PDGF Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Signaling by PDGFWP51:Regulation of Actin Cytoskeleton
|
|
Endochondral Ossification
|
|
Mesodermal Commitment Pathway
|
|
Hair Follicle Development: Induction (Part 1 of 3)
|
|
Integrated Pancreatic Cancer Pathway
|
|
Neural Crest Differentiation
|
|
Signaling by FGFRWP51:Regulation of Actin Cytoskeleton
|
|
Hair Follicle Development: Organogenesis (Part 2 of 3)
|
|
Cardiac Progenitor Differentiation
|
|
Allograft Rejection
|
|
Signaling by PDGF
|
|
AngiogenesisWP304:Kit receptor signaling pathway
|
|
Differentiation Pathway
|
|
Signaling by SCF-KIT
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBaseWP306:Focal Adhesion
|
|
Nifedipine Activity
|
|
Signaling by VEGF
|
|
AngiogenesisWP306:Focal Adhesion
|
|
AngiogenesisWP673:ErbB Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
Notch Signaling Pathway
|
|
EPO Receptor Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Kit receptor signaling pathway
|
|
Pregnane X Receptor pathway
|
|
Aryl Hydrocarbon Receptor Pathway
|
|
IL-3 Signaling Pathway
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Polycystic Kidney Disease Pathway
|
|
Alpha 6 Beta 4 signaling pathway
|
|
BDNF signaling pathway
|
|
Oncostatin M Signaling Pathway
|
|
Interleukin-11 Signaling Pathway
|
|
AGE/RAGE pathway
|
|
TSLP Signaling Pathway
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrin-mediated Cell Adhesion
|
|
Angiogenesis
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. |
|---|
