Drug Information

Drug General Information
Drug ID
D0C2GE
Former ID
DIB019613
Drug Name
compound 8h
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531959]
Structure
Download
2D MOL
Formula
C25H26ClN5O
InChI
InChI=1S/C25H26ClN5O/c1-2-31-13-9-18(10-14-31)29-19-7-8-21-20(15-19)23(25(32)30-21)22(24-27-11-12-28-24)16-3-5-17(26)6-4-16/h3-8,11-12,15,18,29H,2,9-10,13-14H2,1H3,(H,27,28)(H,30,32)
InChIKey
XHCPCYVQXFHJAU-UHFFFAOYSA-N
PubChem Compound ID
67161540
PubChem Substance ID
160702537, 163370020, 244509596, 249565855
Target and Pathway
Target(s) FL cytokine receptor Target Info Inhibitor [531959]
Vascular endothelial growth factor receptor 3 Target Info Inhibitor [531959]
Beta platelet-derived growth factor receptor Target Info Inhibitor [531959]
Basic fibroblast growth factor receptor 1 Target Info Inhibitor [531959]
ribosomal protein S6 kinase, 90kDa, polypeptide 3 Target Info Inhibitor [531959]
mitogen-activated protein kinase kinase kinase kinase 3 Target Info Inhibitor [531959]
Alpha platelet-derived growth factor receptor Target Info Inhibitor [531959]
Mast/stem cell growth factor receptor Target Info Inhibitor [531959]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [531959]
mRNA of VEGFR1 Target Info Inhibitor [531959]
Proto-oncogene tyrosine-protein kinase SRC Target Info Inhibitor [531959]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Focal adhesionhsa04010:MAPK signaling pathway
Ras signaling pathway
Calcium signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Proteoglycans in cancer
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
Endocytosis
Choline metabolism in cancerhsa04014:Ras signaling pathway
Melanogenesis
VEGF signaling pathway
Proteoglycans in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Rheumatoid arthritishsa04012:ErbB signaling pathway
Chemokine signaling pathway
Tight junction
Platelet activation
GABAergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Tuberculosis
Hepatitis B
Viral carcinogenesis
NetPath Pathway TNFalpha Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_15:IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathwayP00005:Angiogenesis
FGF signaling pathwayP00005:Angiogenesis
VEGF signaling pathwayP00005:Angiogenesis
Cadherin signaling pathway
Integrin signalling pathway
Parkinson disease
CCKR signaling map ST
Pathway Interaction Database VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endotheliumptp1bpathway:Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling networkglypican_1pathway:Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathwayatf2_pathway:ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling networkcmyb_pathway:C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)hif2pathway:HIF-2-alpha transcription factor network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
HIF-2-alpha transcription factor network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2endothelinpathway:Endothelins
Signaling events mediated by PRL
LPA receptor mediated events
Atypical NF-kappaB pathway
Glypican 1 network
Plasma membrane estrogen receptor signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
EPHB forward signaling
Regulation of p38-alpha and p38-beta
CDC42 signaling events
Signaling events regulated by Ret tyrosine kinase
Arf6 signaling events
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
Netrin-mediated signaling events
Alpha9 beta1 integrin signaling events
CXCR4-mediated signaling events
EGF receptor (ErbB1) signaling pathway
Class I PI3K signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Regulation of Androgen receptor activity
E-cadherin signaling in the nascent adherens junction
amb2 Integrin signaling
ErbB1 downstream signaling
ErbB2/ErbB3 signaling events
EPHA forward signaling
E-cadherin signaling in keratinocytes
Nongenotropic Androgen signaling
Internalization of ErbB1
CXCR3-mediated signaling events
Syndecan-2-mediated signaling events
Class I PI3K signaling events mediated by Akt
Syndecan-3-mediated signaling events
Ephrin B reverse signaling
Trk receptor signaling mediated by PI3K and PLC-gamma
EPHA2 forward signaling
Alpha-synuclein signaling
FGF signaling pathway
Alpha4 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinase
Reactome VEGF binds to VEGFR leading to receptor dimerizationR-HSA-1257604:PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
Regulation of KIT signaling
RAF/MAP kinase cascadeR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
WikiPathways Signaling by VEGFWP51:Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
Osteoblast Signaling
Focal Adhesion
PIP3 activates AKT signaling
PDGF Pathway
Signaling Pathways in Glioblastoma
Signaling by PDGFWP51:Regulation of Actin Cytoskeleton
Endochondral Ossification
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
Neural Crest Differentiation
Signaling by FGFRWP51:Regulation of Actin Cytoskeleton
Hair Follicle Development: Organogenesis (Part 2 of 3)
Cardiac Progenitor Differentiation
Allograft Rejection
Signaling by PDGF
AngiogenesisWP304:Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP306:Focal Adhesion
Nifedipine Activity
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
AngiogenesisWP673:ErbB Signaling Pathway
Senescence and Autophagy in Cancer
Notch Signaling Pathway
EPO Receptor Signaling
EGF/EGFR Signaling Pathway
TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Pregnane X Receptor pathway
Aryl Hydrocarbon Receptor Pathway
IL-3 Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Polycystic Kidney Disease Pathway
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
Oncostatin M Signaling Pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TSLP Signaling Pathway
Arylhydrocarbon receptor (AhR) signaling pathway
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
Integrin-mediated Cell Adhesion
Angiogenesis
Androgen receptor signaling pathway
References
Ref 531959The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85.
Ref 531959The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85.

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