Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0C0CE
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| Former ID |
DIB004845
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| Drug Name |
Activated recombinant FVII-albumin fusion protein
|
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| Synonyms |
CSL-689; Activated recombinant FVII-albumin fusion protein (hemophilia); Activated recombinant FVII-albumin fusion protein (hemophilia), CSL Behring; RVIIa-FP (hemophilia), CSL Behring; Recombinant factor VIIa/human albumin fusion protein (hemophilia), CSL Behring
|
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| Indication | Hemophilia [ICD9: 286; ICD10:D66-D68] | Phase 2/3 | [1] | ||
| Company |
Csl behring
|
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| Target and Pathway | |||||
| Target(s) | Coagulation factor VII | Target Info | Modulator | [2] | |
| Serum albumin | Target Info | Modulator | [2] | ||
| KEGG Pathway | Complement and coagulation cascades | ||||
| PANTHER Pathway | Angiogenesis | ||||
| Blood coagulation | |||||
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | ||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| Extrinsic Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-114608:Platelet degranulation | |||||
| Recycling of bile acids and salts | |||||
| HDL-mediated lipid transport | |||||
| Scavenging of heme from plasma | |||||
| WikiPathways | Complement and Coagulation Cascades | ||||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | |||||
| Blood Clotting Cascade | |||||
| Formation of Fibrin Clot (Clotting Cascade) | |||||
| Circadian Clock | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient NetworkWP2806:Human Complement System | |||||
| Binding and Uptake of Ligands by Scavenger Receptors | |||||
| Lipid digestion, mobilization, and transport | |||||
| Transport of vitamins, nucleosides, and related molecules | |||||
| Bile acid and bile salt metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT02484638) Study of Recombinant Factor VIIa Fusion Protein (rVIIa-FP, CSL689) for On-demand Treatment of Bleeding Episodes in Patients With Hemophilia A or B With Inhibitors. | ||||
| REF 2 | ClinicalTrials.gov (NCT01542619) A Safety and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor VIIa With Albumin (rVIIa-FP) in Healthy Male Volunteers. U.S. National Institutes of Health. | ||||
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