Drug General Information
Drug ID	D0BM4F
Former ID	DNC005637
Drug Name	Phenyl-(5-phenyl-oxazol-2-yl)-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527458]
Structure		Download 2D MOL 3D MOL
Formula	C15H12N2O
Canonical SMILES	C1=CC=C(C=C1)C2=CN=C(O2)NC3=CC=CC=C3
InChI	1S/C15H12N2O/c1-3-7-12(8-4-1)14-11-16-15(18-14)17-13-9-5-2-6-10-13/h1-11H,(H,16,17)
InChIKey	HFICAVMUTYFODG-UHFFFAOYSA-N
PubChem Compound ID	5329404
Target and Pathway
Target(s)	mRNA of VEGFR1	Target Info	Inhibitor	[527458]
	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[527458]
	Vascular endothelial growth factor receptor 3	Target Info	Inhibitor	[527458]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	HIF-1 signaling pathway
	Endocytosis
	PI3K-Akt signaling pathway
	Focal adhesion
	Transcriptional misregulation in cancer
	Rheumatoid arthritishsa04014:Ras signaling pathway
	VEGF signaling pathway
	Proteoglycans in cancerhsa04014:Ras signaling pathway
NetPath Pathway	IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	Glypican 1 network
	HIF-2-alpha transcription factor network
	S1P3 pathway
	VEGF and VEGFR signaling network
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY networkvegf_vegfr_pathway:VEGF and VEGFR signaling network
	VEGFR3 signaling in lymphatic endothelium
Reactome	Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerization
WikiPathways	Focal Adhesion
	Signaling by VEGF
	AngiogenesisWP306:Focal Adhesion
	Nifedipine Activity
	Cardiac Progenitor Differentiation
	AngiogenesisWP1919:Signaling by VEGF
References
Ref 527458	J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
Ref 527458	J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.