Drug Information

Drug General Information
Drug ID
D0BF9K
Former ID
DNC000136
Drug Name
ABX-IL8
Drug Type
Antibody
Indication Melanoma [ICD9: 172; ICD10:C43] Phase 2 [521511]
Target and Pathway
Target(s) Interleukin-8 Target Info [535504]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NF-kappa B signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Legionellosis
Chagas disease (American trypanosomiasis)
Malaria
Amoebiasis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Transcriptional misregulation in cancer
Bladder cancer
Rheumatoid arthritis
NetPath Pathway IL-7 Signaling Pathway
IL5 Signaling Pathway
IL1 Signaling Pathway
TSH Signaling Pathway
IL2 Signaling Pathway
IL3 Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
TSLP Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
CCKR signaling map ST
Pathway Interaction Database LPA receptor mediated events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Glucocorticoid receptor regulatory network
ATF-2 transcription factor network
IL8-mediated signaling events
AP-1 transcription factor network
IL8- and CXCR2-mediated signaling events
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling events
Syndecan-3-mediated signaling events
IL8- and CXCR1-mediated signaling events
Reactome Senescence-Associated Secretory Phenotype (SASP)
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
ATF4 activates genes
G alpha (i) signalling events
WikiPathways Toll-like receptor signaling pathway
SIDS Susceptibility Pathways
Senescence and Autophagy in Cancer
IL-3 Signaling Pathway
Bladder Cancer
Activation of Genes by ATF4
EBV LMP1 signaling
Spinal Cord Injury
Corticotropin-releasing hormone
Allograft Rejection
TSLP Signaling Pathway
GPCR ligand binding
GPCR downstream signaling
Regulation of toll-like receptor signaling pathway
References
Ref 521511ClinicalTrials.gov (NCT00035828) A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD. U.S. National Institutes of Health.
Ref 535504Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002 Jul;161(1):125-34.

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