Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0BD3U
|
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| Former ID |
DNC004300
|
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| Drug Name |
SDZ-64-412
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Terminated | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C28H28N2O3
|
||||
| InChI |
InChI=1S/C28H28N2O3/c1-31-25-16-20(17-26(32-2)27(25)33-3)9-8-19-10-12-21(13-11-19)24-18-22-6-4-5-7-23(22)28-29-14-15-30(24)28/h4-7,10-13,16-18H,8-9,14-15H2,1-3H3
|
||||
| InChIKey |
FKRBSORUVOGNEK-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1855). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000046) | ||||
| REF 3 | J Med Chem. 1993 Oct 15;36(21):3098-102.Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists. | ||||
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