Drug General Information
Drug ID	D0B8HS
Former ID	DCL000065
Drug Name	BCX-4208
Drug Type	Small molecular drug
Indication	Gout; Moderate-to-severe plaque psoriasis [ICD9: 274.00274.1274.8274.9, 696; ICD10:M10, L40]		Phase 2	[523572]
Company	BioCryst Pharma.
Structure		Download 2D MOL 3D MOL
Formula	C12H16N4O3
Canonical SMILES	C1C(C(CN1CC2=CNC3=C2NC=NC3=O)O)CO
InChIKey	AFNHHLILYQEHKK-BDAKNGLRSA-N
PubChem Compound ID	447268
PubChem Substance ID	854457, 11532089, 11532091, 11532093, 15189141, 36889471, 46392572, 46504209, 49845925, 50943403, 99289526, 99453859, 103578901, 104637760, 134345506, 144071783, 162108916, 162870974, 172232524, 198987557, 223732508, 226792054, 248726052
Target and Pathway
Target(s)	Purine nucleoside phosphorylase	Target Info	Inhibitor	[549732]
BioCyc Pathway	Arsenate detoxification I (glutaredoxin)
	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Purine deoxyribonucleosides degradation
	Purine ribonucleosides degradation to ribose-1-phosphate
	Guanosine nucleotides degradation
	Adenosine nucleotides degradation
	Superpathway of purine nucleotide salvage
	Adenine and adenosine salvage III
	Guanine and guanosine salvage
KEGG Pathway	Purine metabolism
	Pyrimidine metabolism
	Nicotinate and nicotinamide metabolism
	Metabolic pathways
NetPath Pathway	TCR Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Adenine and hypoxanthine salvage pathway
	Xanthine and guanine salvage pathway
PathWhiz Pathway	Purine Metabolism
	Nicotinate and Nicotinamide Metabolism
Reactome	Purine salvage
	Purine catabolism
WikiPathways	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Metabolism of nucleotides
References
Ref 523572	ClinicalTrials.gov (NCT01407874) A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiency. U.S. National Institutes of Health.
Ref 549732	BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent. 50th ASH Annual Meeting and Exposition. 2008.

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