| Drug General Information |
| Drug ID |
D0B7OW
|
| Former ID |
DIB020891
|
| Drug Name |
sakuranetin
|
| Synonyms |
4',5-dihydroxy-7-methoxyflavanone
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C16H14O5
|
| InChI |
InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3/t14-/m0/s1
|
| InChIKey |
DJOJDHGQRNZXQQ-AWEZNQCLSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
12021, 611572, 1057630, 8195774, 26746503, 43129485, 49658592, 51053348, 56435917, 57319159, 57390070, 74381871, 87557703, 99444988, 103139308, 103581404, 104147009, 104355570, 117599004, 118047260, 119525460, 135033686, 135652713, 135836291, 137017038, 141740306, 160969553, 164824556, 179230639, 184583132, 198955160, 223464971, 223529074, 226863659, 241058937
|
| Target and Pathway |
| Target(s) |
Adenosine A2b receptor |
Target Info |
Antagonist |
[2]
|
|---|
| Adenosine A1 receptor |
Target Info |
Antagonist |
[2]
|
| Adenosine A3 receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
|
Alcoholismhsa04022:cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Morphine addiction
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
RANKL Signaling Pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Pathway Interaction Database
|
C-MYB transcription factor network
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Reactome
|
Adenosine P1 receptors
|
|
G alpha (s) signalling events
|
|
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP80:Nucleotide GPCRs
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 412). |
|---|
| REF 2 | J Med Chem. 1996 Jun 7;39(12):2293-301.Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. |
|---|
