Drug Information

Drug General Information
Drug ID
D0B6KT
Former ID
DIB020678
Drug Name
PF-06454589
Synonyms
compound 28 [PMID: 25353650]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543048]
Structure
Download
2D MOL
Formula
C14H16N6O
InChI
InChI=1S/C14H16N6O/c1-19-8-10(6-18-19)11-7-15-13-12(11)14(17-9-16-13)20-2-4-21-5-3-20/h6-9H,2-5H2,1H3,(H,15,16,17)
InChIKey
VNWKCLDQBNSJJO-UHFFFAOYSA-N
PubChem Compound ID
72706837
PubChem Substance ID
172107967, 224723368, 240349730, 249565398, 252166507
Target and Pathway
Target(s) leucine-rich repeat kinase 2 Target Info Inhibitor [533011]
References
Ref 543048(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8295).
Ref 533011Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.