Drug General Information
Drug ID	D0B5OK
Former ID	DNC013468
Drug Name	6-phenylethynyl-nicotinic acid methyl ester
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529241]
Structure		Download 2D MOL 3D MOL
Formula	C15H11NO2
Canonical SMILES	COC(=O)C1=CN=C(C=C1)C#CC2=CC=CC=C2
InChI	1S/C15H11NO2/c1-18-15(17)13-8-10-14(16-11-13)9-7-12-5-3-2-4-6-12/h2-6,8,10-11H,1H3
InChIKey	DRFBUAIOGNADQC-UHFFFAOYSA-N
PubChem Compound ID	14343219
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[529241]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529241	J Med Chem. 2008 Feb 14;51(3):634-47. Epub 2008 Jan 4.Positive and negative modulation of group I metabotropic glutamate receptors.
Ref 529241	J Med Chem. 2008 Feb 14;51(3):634-47. Epub 2008 Jan 4.Positive and negative modulation of group I metabotropic glutamate receptors.

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