Drug Information

Drug General Information
Drug ID
D0B0OY
Former ID
DNC000990
Drug Name
Naphthoquinone analogs
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535050]
Structure
Download
2D MOL

3D MOL
Formula
C15H22N2O3
Canonical SMILES
CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC
InChI
1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
InChIKey
PDMUULPVBYQBBK-UHFFFAOYSA-N
CAS Number
CAS 29925-17-5
PubChem Compound ID
5087
PubChem Substance ID
5146344, 7980528, 8153130, 11121423, 11121903, 11362492, 11364754, 11365054, 11367316, 11367616, 11369878, 11370255, 11370256, 11373070, 11373217, 11375778, 11378043, 11491641, 11495654, 14824380, 17404767, 24278195, 26613194, 26747110, 26751709, 26759463, 29224155, 46500386, 47216899, 47662431, 47810881, 48185112, 48259380, 48259381, 48478658, 50067170, 50070586, 50071197, 50104396, 50104397, 50104398, 50104399, 53777310, 53789843, 53800559, 57322600, 80110624, 85084418, 85230941, 85787734
Target and Pathway
Target(s) M-phase inducer phosphatase 1 Target Info Inhibitor [535050]
KEGG Pathway Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database E2F transcription factor network
ATR signaling pathway
Validated targets of C-MYC transcriptional activation
ATM pathway
Reactome E2F mediated regulation of DNA replication
G0 and Early G1
Polo-like kinase mediated events
Cyclin B2 mediated events
Activation of ATR in response to replication stress
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin A/B1 associated events during G2/M transition
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entry
WikiPathways DNA Damage Response
G1 to S cell cycle control
S Phase
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G1-G1/S phases
Cell Cycle
Cell Cycle Checkpoints
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
References
Ref 535050Role of the Cdc25A phosphatase in human breast cancer. J Clin Invest. 2000 Sep;106(6):753-61.
Ref 535050Role of the Cdc25A phosphatase in human breast cancer. J Clin Invest. 2000 Sep;106(6):753-61.

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