Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B0GC
|
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| Former ID |
DIB000477
|
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| Drug Name |
E-0722
|
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| Synonyms |
Methosorbinil; E-79175; M-79175
|
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| Drug Type |
Small molecular drug
|
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| Indication | Diabetic cataract [ICD10:E10.36, E11.36] | Terminated | [1] | ||
| Company |
Eisai Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C12H11FN2O3
|
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| Canonical SMILES |
[C@]12(C(=O)NC(=O)N1)c1c(O[C@@H](C2)C)ccc(c1)F
|
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| CAS Number |
CAS 102916-95-0
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Aldose reductase | Target Info | Modulator | [2] | |
| BioCyc Pathway | Methylglyoxal degradation III | ||||
| Acetone degradation I (to methylglyoxal) | |||||
| KEGG Pathway | Pentose and glucuronate interconversions | ||||
| Fructose and mannose metabolism | |||||
| Galactose metabolism | |||||
| Glycerolipid metabolism | |||||
| Metabolic pathways | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| PathWhiz Pathway | Fructose and Mannose Degradation | ||||
| Pyruvate Metabolism | |||||
| Pterine Biosynthesis | |||||
| Glycerolipid Metabolism | |||||
| Galactose Metabolism | |||||
| WikiPathways | Metapathway biotransformation | ||||
| Polyol Pathway | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004685) | ||||
| REF 2 | Aldose reductase inhibitors and prevention of galactose cataracts in rats. Invest Ophthalmol Vis Sci. 1989 Jul;30(7):1623-32. | ||||
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