Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0AM8W
|
||||
| Former ID |
DIB010275
|
||||
| Drug Name |
Zanapezil
|
||||
| Synonyms |
TAK-147
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Discontinued in Phase 3 | [1] | ||
| Company |
Takeda Pharmaceutical Co Ltd
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C25H32N2O
|
||||
| Canonical SMILES |
c12cc(C(=O)CCC3CCN(Cc4ccccc4)CC3)ccc2CCCCN1.C(=O)(/C=C/<br />C(=O)O)O
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Acetylcholinesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Cholinergic synapse | |||||
| PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| Pathway Interaction Database | ATF-2 transcription factor network | ||||
| PathWhiz Pathway | Phospholipid Biosynthesis | ||||
| WikiPathways | Monoamine Transport | ||||
| Biogenic Amine Synthesis | |||||
| Acetylcholine Synthesis | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004496) | ||||
| REF 2 | Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats. Br J Pharmacol. 2005 Aug;145(8):1035-44. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.