Drug General Information
Drug ID	D0AM8W
Former ID	DIB010275
Drug Name	Zanapezil
Synonyms	TAK-147
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Discontinued in Phase 3	[545741]
Company	Takeda Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C25H32N2O
Canonical SMILES	c12cc(C(=O)CCC3CCN(Cc4ccccc4)CC3)ccc2CCCCN1.C(=O)(/C=C/<br />C(=O)O)O
PubChem Compound ID	198752
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[527590]
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
PathWhiz Pathway	Phospholipid Biosynthesis
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 545741	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004496)
Ref 527590	Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats. Br J Pharmacol. 2005 Aug;145(8):1035-44.

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