Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0AK4H
|
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| Former ID |
DIB015210
|
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| Drug Name |
AMG-429
|
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| Synonyms |
AMG-429; KDR inhibitors (anticancer), Amgen; VEGFR-2 inhibitors (anticancer); VEGFR-2 inhibitors (anticancer), Amgen
|
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [543499] | ||
| Company |
Amgen Inc
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(c(cc2c(c1)c(ccn2)Oc1cc2c(cc1)c(nn2C)NC(=O)c1cc(ccc1)<br />C(F)(F)F)OC)OC
|
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | Inhibitor | [543499] | |
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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