Drug Information

Drug General Information
Drug ID
D0AB7G
Former ID
DIB008196
Drug Name
MCI-826
Synonyms
(E)-2,2-Diethyl-3'-[2-[2-(4-isopropyl)thiazolyl]ethenyl]succinanilic acid; (E)-2,2-Diethyl-N-[3-[2-(4-isopropylthiazol-2-yl)vinyl]phenyl]succinamic acid
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [544954]
Structure
Download
2D MOL

3D MOL
Formula
C22H28N2O3S
Canonical SMILES
CCC(CC)(CC(=O)NC1=CC=CC(=C1)C=CC2=NC(=CS2)C(C)C)C(=O)O
InChI
1S/C22H28N2O3S/c1-5-22(6-2,21(26)27)13-19(25)23-17-9-7-8-16(12-17)10-11-20-24-18(14-28-20)15(3)4/h7-12,14-15H,5-6,13H2,1-4H3,(H,23,25)(H,26,27)/b11-10+
InChIKey
PGLNVMJTDKEOBE-ZHACJKMWSA-N
PubChem Compound ID
6439428
PubChem Substance ID
11968295, 14903650, 43032357, 80003834, 114558662, 135089263, 144087397, 234536222, 234536238, 241034666
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Antagonist [526754], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 544954Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001711)
Ref 526754Leukotriene receptors in the skin of rats differ from those of mouse skin or rat stomach strip. Eur J Pharmacol. 1992 Oct 20;221(2-3):333-42.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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