| Drug General Information |
| Drug ID |
D0A8MD
|
| Former ID |
DNC002522
|
| Drug Name |
2-HYDROXY-3,5-DIIODOBENZOIC ACID
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C7H4I2O3
|
| Canonical SMILES |
C1=C(C=C(C(=C1I)O)C(=O)O)I
|
| InChI |
1S/C7H4I2O3/c8-3-1-4(7(11)12)6(10)5(9)2-3/h1-2,10H,(H,11,12)
|
| InChIKey |
DHZVWQPHNWDCFS-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
72292, 607492, 3132925, 4389280, 7887056, 8001989, 8027948, 8156100, 10506878, 15004752, 24893385, 29227299, 46504394, 46507861, 49830812, 50045253, 50365425, 56367325, 57325142, 57939281, 85085480, 85247016, 87568153, 88683727, 92710266, 103119197, 104248422, 104318355, 105596734, 117512023, 118560201, 125340212, 126546855, 126632044, 126688027, 127737700, 130935160, 134974765, 134980661, 137021197, 140219105, 143454025, 144024740, 160787096, 160967661, 162176777, 162271333, 163304611, 163371123, 163726658
|
| Target and Pathway |
| Target(s) |
Endothelin-1 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
|
Renin secretion
|
|
Pathways in cancer
|
|
NetPath Pathway
|
IL4 Signaling Pathway
|
|
PANTHER Pathway
|
Endothelin signaling pathway
|
|
Pathway Interaction Database
|
Endothelins
|
|
EGFR-dependent Endothelin signaling events
|
|
Reactome
|
Peptide ligand-binding receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Prostaglandin Synthesis and Regulation
|
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Peptide GPCRs
|
|
Endothelin Pathways
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | Allosteric inhibition of endothelin <span class="caps">ETA</span> receptors by 3, 5-dibromosalicylic acid. Mol Pharmacol. 2000 Dec;58(6):1461-9. |
|---|
