Drug General Information
Drug ID
D0A6DI
Former ID
DIB003993
Drug Name
RG-1662
Synonyms
GABA-A agonist (Alzheimer's disease), Roche
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 2 [525248]
Company
Roche Holding AG
Structure
Download
2D MOL

3D MOL

Target and Pathway
Target(s) Gamma-aminobutyric-acid receptor alpha-5 subunit Target Info Agonist [551418]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 525248ClinicalTrials.gov (NCT02484703) A Study of RG1662 in Down Syndrome Among Children 6 to 11 Years of Age.
Ref 551418RG1662, a Selective GABAA alpha5 Receptor Negative Allosteric Modulator, Increases Gamma Power in Young Adults with Down Syndrome. Neurology April 6, 2015 vol. 84 no. 14.

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