Drug Information

Drug General Information
Drug ID
D0A4OT
Former ID
DIB000794
Drug Name
TAMOLARIZINE HYDROCHLORIDE
Synonyms
NC-1100; Tamolarizine hydrochloride < Rec INNM >; Rac-alpha-(3,4-Dimethoxyphenyl)-4-(diphenylmethyl)-1-piperazineethanol dihydrochloride; Rac-1-(3,4-Dimethoxyphenyl)-2-(4-diphenylmethyl-1-piperazinyl)ethanol dihydrochloride
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Discontinued in Phase 2 [544615]
Structure
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2D MOL

3D MOL
Formula
C27H34Cl2N2O3
Canonical SMILES
COC1=C(C=C(C=C1)C(CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)<br />O)OC.Cl.Cl
InChI
1S/C27H32N2O3.2ClH/c1-31-25-14-13-23(19-26(25)32-2)24(30)20-28-15-17-29(18-16-28)27(21-9-5-3-6-10-21)22-11-7-4-8-12-22;;/h3-14,19,24,27,30H,15-18,20H2,1-2H3;2*1H
InChIKey
ZIGNSXDSBVYYFD-UHFFFAOYSA-N
CAS Number
CAS 93035-33-7
PubChem Compound ID
146395
PubChem Substance ID
10249219, 12013858, 14762306, 46223623, 50013296, 50013297, 50013298, 50013299, 57346365, 77260712, 104413903, 135103460, 228325042
Target and Pathway
Target(s) Calcium channel Target Info Blocker [525821], [551871]
References
Ref 544615Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000299)
Ref 525821Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist. Jpn J Pharmacol. 2000 Mar;82(3):265-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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