Drug Information

Drug General Information
Drug ID
D0A3KA
Former ID
DNC008137
Drug Name
Salvinorin B 2,2,2-trifluoroethoxymethyl ether
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529133]
Structure
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2D MOL

3D MOL
Formula
C24H29F3O8
Canonical SMILES
CC12CCC3C(=O)OC(CC3(C1C(=O)C(CC2C(=O)OC)OCOCC(F)(F)F)C)<br />C4=COC=C4
InChI
1S/C24H29F3O8/c1-22-6-4-14-21(30)35-17(13-5-7-32-10-13)9-23(14,2)19(22)18(28)16(8-15(22)20(29)31-3)34-12-33-11-24(25,26)27/h5,7,10,14-17,19H,4,6,8-9,11-12H2,1-3H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
InChIKey
RUKCGYZDLPIDHQ-AGQYDFLVSA-N
PubChem Compound ID
44456346
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Inhibitor [529133]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 529133Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. Epub 2007 Oct 24.Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.
Ref 529133Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. Epub 2007 Oct 24.Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.

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