| Drug General Information |
| Drug ID |
D0A2VG
|
| Former ID |
DIB018356
|
| Drug Name |
[3H]nemonapride
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C21H26ClN3O2
|
| InChI |
InChI=1S/C21H26ClN3O2/c1-14-18(9-10-25(14)13-15-7-5-4-6-8-15)24-21(26)16-11-17(22)19(23-2)12-20(16)27-3/h4-8,11-12,14,18,23H,9-10,13H2,1-3H3,(H,24,26)/t14-,18-/m1/s1
|
| InChIKey |
KRVOJOCLBAAKSJ-RDTXWAMCSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
583304, 7848531, 7979155, 12013018, 14927531, 46232157, 47880153, 48029708, 49711016, 49876079, 56486820, 57348267, 79858055, 113434821, 134338687, 134339508, 135112637, 135311102, 135610978, 135651188, 135698312, 137271277, 177749702, 179151074, 194149378, 198975435, 227838955, 241135381, 252542961
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Antagonist |
[2]
|
|---|
| D(3) dopamine receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
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cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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Gap junction
|
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Dopaminergic synapse
|
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Parkinson's disease
|
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Cocaine addiction
|
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
|
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Dopamine receptors
|
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
|
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WikiPathways
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Hypothetical Network for Drug Addiction
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
|
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 962). |
|---|
| REF 2 | Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole. J Neurochem. 2003 Nov;87(3):631-41. |
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