Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0A0SI
|
||||
| Former ID |
DNCL003393
|
||||
| Drug Name |
BAY 85-8501
|
||||
| Indication | Bronchiectasis [ICD9: 494, 748.61; ICD10:J47, Q33.4] | Phase 2 | [1] | ||
| Company |
Bayer HealthCare Pharmaceuticals
|
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| Structure |
|
Download2D MOL |
|||
| Target and Pathway | |||||
| Target(s) | Leukocyte elastase | Target Info | Modulator | [2] | |
| KEGG Pathway | Transcriptional misregulation in cancer | ||||
| Systemic lupus erythematosus | |||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
| C-MYB transcription factor network | |||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
| Human Complement System | |||||
| Degradation of collagen | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037600) | ||||
| REF 2 | Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY??5-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73. | ||||
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