Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09ZLZ
|
||||
| Former ID |
DIB014159
|
||||
| Drug Name |
RAD-140
|
||||
| Synonyms |
RAD-35010; Selective androgen receptor modulators (oral, sarcopenia/osteoporosis), Radius Health
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] | Investigative | [1] | ||
| Company |
Radius Health Inc
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H16ClN5O2
|
||||
| Canonical SMILES |
C(#N)c1c(c(c(cc1)N[C@H]([C@H](C)O)c1oc(nn1)c1ccc(cc1)C#<br />N)C)Cl
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Androgen receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | Oocyte meiosis | ||||
| Pathways in cancer | |||||
| Prostate cancer | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| AndrogenReceptor Signaling Pathway | |||||
| FSH Signaling Pathway | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Coregulation of Androgen receptor activity | |||||
| Regulation of Androgen receptor activity | |||||
| Nongenotropic Androgen signaling | |||||
| Regulation of nuclear beta catenin signaling and target gene transcription | |||||
| FOXA1 transcription factor network | |||||
| Notch-mediated HES/HEY network | |||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Integrated Pancreatic Cancer Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Nuclear Receptors | |||||
| Androgen receptor signaling pathway | |||||
| References | |||||
| REF 1 | Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010 Dec 2;2(2):124-9. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.