Drug General Information
Drug ID
D09YDM
Former ID
DNC000385
Drug Name
Camptothecin
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 3 [528447]
Structure
Download
2D MOL

3D MOL

Formula
C20H16N2O4
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
InChI
1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChIKey
VSJKWCGYPAHWDS-FQEVSTJZSA-N
CAS Number
CAS 2086-83-1
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:16118
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Toposisomerase-1 Target Info Modulator [528447]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 528447Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.
Ref 528447Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.

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