Drug General Information
Drug ID	D09WVV
Former ID	DNC011081
Drug Name	N1-(2-aminoethyl)ethane-1,2-diamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530998]
Structure		Download 2D MOL 3D MOL
Formula	C4H13N3
Canonical SMILES	C(CNCCN)N
InChI	1S/C4H13N3/c5-1-3-7-4-2-6/h7H,1-6H2
InChIKey	RPNUMPOLZDHAAY-UHFFFAOYSA-N
PubChem Compound ID	8111
Target and Pathway
Target(s)	Carbonic anhydrase	Target Info	Inhibitor	[530998]
	Carbonic anhydrase XII	Target Info	Inhibitor	[530998]
	Carbonic anhydrase IX	Target Info	Inhibitor	[530998]
	Carbonic anhydrase VI	Target Info	Inhibitor	[530998]
	Carbonic anhydrase XIV	Target Info	Inhibitor	[530998]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor network
Reactome	Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2877:Vitamin D Receptor Pathway
	Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
References
Ref 530998	J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Ref 530998	J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.

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