Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09WCE
|
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| Former ID |
DIB006068
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| Drug Name |
IS-159
|
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| Drug Type |
Small molecular drug
|
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| Indication | Migraine [ICD9: 346; ICD10:G43] | Discontinued in Phase 2 | [1] | ||
| Company |
Immunotech SA
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C23H27N5O5
|
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| Canonical SMILES |
[nH]1cc(c2c1ccc(c2)OCC(=O)N[C@H](C(=O)NCC(=O)N)Cc1ccc(c<br />c1)O)CCN
|
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| CAS Number |
CAS 133790-13-3
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1B receptor | Target Info | Modulator | ||
| 5-hydroxytryptamine 1D receptor | Target Info | Modulator | |||
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapsehsa04024:cAMP signaling pathway | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| 5HT1 type receptor mediated signaling pathway | |||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005786) | ||||
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