Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09UMA
|
||||
| Former ID |
DNC004281
|
||||
| Drug Name |
IMAZODAN
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C13H13ClN4O
|
||||
| Canonical SMILES |
C1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3
|
||||
| InChI |
1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
|
||||
| InChIKey |
VXMYWVMXSWJFCV-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [2] | |
| CGMP-dependent3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [2] | ||
| CGMP-inhibited 3',5'-cyclic phosphodiesterase A | Target Info | Inhibitor | [3] | ||
| KEGG Pathway | Purine metabolism | ||||
| cGMP-PKG signaling pathwayhsa00230:Purine metabolism | |||||
| cGMP-PKG signaling pathway | |||||
| Morphine addictionhsa00230:Purine metabolism | |||||
| cAMP signaling pathway | |||||
| Morphine addiction | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling PathwayNetPath_23:TSH Signaling Pathway | ||||
| Reactome | cGMP effectsR-HSA-418457:cGMP effects | ||||
| G alpha (s) signalling eventsR-HSA-418457:cGMP effects | |||||
| G alpha (s) signalling events | |||||
| WikiPathways | miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000379) | ||||
| REF 2 | J Med Chem. 1984 Sep;27(9):1099-101.Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure. | ||||
| REF 3 | J Med Chem. 1992 Feb 21;35(4):620-8.3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.