Drug General Information
Drug ID
D09UEM
Former ID
DIB020356
Drug Name
minodronic acid
Synonyms
YH 529; ONO 5920; BPH 261
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540148]
Structure
Download
2D MOL
Formula
C9H12N2O7P2
InChI
InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)
InChIKey
VMMKGHQPQIEGSQ-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Geranyltranstransferase Target Info Inhibitor [529700]
Farnesyl pyrophosphatesynthetase Target Info Inhibitor [530855]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid BiosynthesisPW000050:Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)R-HSA-191273:Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)WP2706:Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 540148(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3164).
Ref 529700Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607.
Ref 530855Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64.

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