Drug Information

Drug General Information
Drug ID
D09SUO
Former ID
DIB020977
Drug Name
splitomicin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526230]
Structure
Download
2D MOL
Formula
C13H10O2
InChI
InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
InChIKey
ISFPDBUKMJDAJH-UHFFFAOYSA-N
PubChem Compound ID
5269
PubChem Substance ID
5614465, 8153240, 11114129, 11121743, 11122223, 11362870, 11365432, 11367994, 11370951, 11370952, 11373595, 11376156, 12015614, 15487777, 24724608, 26752214, 26759555, 29224324, 47662436, 47810888, 50104892, 57322688, 74857037, 81055019, 85788291, 91722326, 92310094, 99301006, 99302526, 99375476, 103092662, 103148024, 103297410, 104308751, 117601689, 121363829, 125333607, 132570953, 134964522, 137468463, 160657168, 162023121, 162248340, 163687300, 163835543, 172089098, 175608088, 176236732, 184021964, 223366898
Target and Pathway
Target(s) NAD-dependent deacetylase sirtuin-1 Target Info Inhibitor [530608]
KEGG Pathway FoxO signaling pathway
AMPK signaling pathway
Glucagon signaling pathway
Amphetamine addiction
MicroRNAs in cancer
PANTHER Pathway p53 pathway
Pathway Interaction Database p73 transcription factor network
Signaling events mediated by HDAC Class III
E2F transcription factor network
HIF-2-alpha transcription factor network
Signaling events mediated by HDAC Class I
FoxO family signaling
Regulation of Androgen receptor activity
Regulation of retinoblastoma protein
Reactome RORA activates gene expression
Regulation of HSF1-mediated heat shock response
Circadian Clock
WikiPathways Integrated Pancreatic Cancer Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Androgen receptor signaling pathway
References
Ref 526230Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8.
Ref 530608J Med Chem. 2010 Feb 11;53(3):1407-11.Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.

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