Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09RNP
|
||||
| Former ID |
DCL000667
|
||||
| Drug Name |
GSK 679769
|
||||
| Indication | Incontinence; Anxiety disorder; Chemotherapyinduced emesis; Major depressive disorder [ICD9: 296.2, 296.3, 300, 787, 787.6, 788.3; ICD10:F32, F33, F40-F42, N39.3-N39.4] | Discontinued in Phase 2 | [1] | ||
| Company |
GlaxoSmithKline
|
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| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Measles | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. | ||||
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