Drug Information

Drug General Information
Drug ID
D09QVV
Former ID
DAP000114
Drug Name
Vincristine
Synonyms
LCR; Leurocristine; Marqibo; Oncovine; Tecnocris; VCR; VIN; Vincasar; Vincristina; Vincristinum; Vincrstine; Vincrystine; Vinkristin; Indole alkaloid; Liposomal Vincristine; Onco TCS; Vincristina [DCIT]; Oncovin (TN); Tecnocris (TN); Vincristine (INN); Vincristine [INN:BAN]; Vincristinum [INN-Latin]; Lilly37231 (1:1 sulfate salt); Oncovin (1:1 sulfate salt); Vincasar (1:1 sulfate salt); Vincrex (1:1 sulfate salt); Vincaleukoblastine, 22-oxo-22-Oxovincaleukoblastine; Z-D-Val-Lys(Z)-OH; 22-Oxovincaleukoblastine
Drug Type
Small molecular drug
Indication Acute lymphoblastic leukemia [ICD9: 204.0, 556; ICD10:C91.0] Approved [536556], [541865]
Therapeutic Class
Anticancer Agents
Company
Mayne Pharma Limited
Structure
Download
2D MOL

3D MOL
Formula
C46H56N4O10
InChI
InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
InChIKey
OGWKCGZFUXNPDA-XQKSVPLYSA-N
CAS Number
CAS 57-22-7
PubChem Compound ID
5978
PubChem Substance ID
9413, 598397, 8153716, 11431056, 14717665, 14889382, 26757081, 29224994, 46507033, 48424284, 49854447, 53788615, 56312035, 56314177, 57323093, 74979043, 92309095, 96025362, 104029594, 104310773, 124892473, 124892475, 126687244, 127301091, 127301092, 127301093, 127301094, 127301095, 127301096, 127301097, 127301098, 127301099, 127301100, 127301101, 127301102, 127301103, 127301104, 127301105, 127301106, 127301107, 127301108, 127301109, 127301110, 127301111, 127301112, 127301113, 127301114, 127301115, 127301116, 127301117
ChEBI ID
ChEBI:28445
SuperDrug ATC ID
L01CA02
SuperDrug CAS ID
cas=000057227
Target and Pathway
Target(s) Tubulin beta Target Info Modulator [556264]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 536556Vinflunine, a novel microtubule inhibitor, suppresses calmodulin interaction with the microtubule-associated protein STOP. Biochemistry. 2007 Dec 25;46(51):14899-906. Epub 2007 Dec 4.
Ref 541865(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6785).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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