Drug Information

Drug General Information
Drug ID
D09PYZ
Former ID
DNCL001964
Drug Name
MK-3328
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 1 [522751]
Company
Merck
Structure
Download
2D MOL

3D MOL
Formula
C14H9FN4O
Canonical SMILES
CN1C=CC2=CC(=CN=C21)C3=NC4=C(O3)N=C(C=C4)F
InChI
1S/C14H9FN4O/c1-19-5-4-8-6-9(7-16-12(8)19)13-17-10-2-3-11(15)18-14(10)20-13/h2-7H,1H3/i15-1
InChIKey
WYQHKOHCTMNFAU-HUYCHCPVSA-N
PubChem Compound ID
53243932
PubChem Substance ID
124358193, 136350066, 138405354, 138707080, 163335715, 163643227, 198941028, 237358427
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator [543750]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 522751ClinicalTrials.gov (NCT00954538) Safety, Radiation Dosimetry, Biokinetics, and Effectiveness of [18F]MK3328 (MK-3328-001). U.S. National Institutes of Health.
Ref 543750(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).

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