Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09PTA
|
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| Former ID |
DIB002342
|
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| Drug Name |
HP-290
|
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| Synonyms |
NXX-066
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| Drug Type |
Small molecular drug
|
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| Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Discontinued in Phase 2 | [1] | ||
| Company |
Astra AB; Hoechst AG
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C23H27N3O2
|
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| Canonical SMILES |
[C@]12([C@@H](N(c3c1cc(OC(=O)N1Cc4c(CC1)cccc4)cc3)C)N(C<br />C2)C)C
|
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| CAS Number |
CAS 139314-01-5
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Acetylcholinesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Cholinergic synapse | |||||
| PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| Pathway Interaction Database | ATF-2 transcription factor network | ||||
| PathWhiz Pathway | Phospholipid Biosynthesis | ||||
| WikiPathways | Monoamine Transport | ||||
| Biogenic Amine Synthesis | |||||
| Acetylcholine Synthesis | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006532) | ||||
| REF 2 | NXX-066 in patients with Alzheimer's disease: a bridging study. Life Sci. 1999;64(14):1215-21. | ||||
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