Drug Information
| Drug General Information | |||||
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| Drug ID |
D09PPG
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| Former ID |
DIB007257
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| Drug Name |
Metformin arginine-hemisuccinimide
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| Synonyms |
Metformin; Diap-2; Metformin arginine-hemisuccinate-hemisuccinamide; Metformin arginine-hemisuccinimide (type 2 diabetes); Diap-2 (type 2 diabetes), Arteria; Metformin arginine-hemisuccinimide (type 2 diabetes), Arteria
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| Indication | Type 2 diabetes [ICD9: 250; ICD10:E11] | Approved | [1] | ||
| Company |
Boehringer Ingelheim Pharmaceuticals; Merck; Depomed; Janssen Research & Development; AstraZeneca; Bristol-Myers Squibb
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
C(=N)(NC(=N)N(C)C)N.C(CC(=O)O)C(=O)NC(=N)NCCC[C@H](N)C(<br />=O)O
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| CAS Number |
CAS 657-24-9
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| Target and Pathway | |||||
| Target(s) | Insulin receptor | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| cGMP-PKG signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| FoxO signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| AMPK signaling pathway | |||||
| Adherens junction | |||||
| Insulin signaling pathway | |||||
| Ovarian steroidogenesis | |||||
| Type II diabetes mellitus | |||||
| Non-alcoholic fatty liver disease (NAFLD) | |||||
| Aldosterone-regulated sodium reabsorption | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | ||||
| Insulin/IGF pathway-protein kinase B signaling cascade | |||||
| PI3 kinase pathway | |||||
| Pathway Interaction Database | Insulin Pathway | ||||
| Signaling events mediated by PTP1B | |||||
| Signaling events mediated by TCPTP | |||||
| Insulin-mediated glucose transport | |||||
| PathWhiz Pathway | Insulin Signalling | ||||
| Leucine Stimulation on Insulin Signaling | |||||
| Reactome | IRS activation | ||||
| Signal attenuation | |||||
| Insulin receptor signalling cascade | |||||
| Insulin receptor recycling | |||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| Insulin Signaling | |||||
| Nanoparticle triggered autophagic cell death | |||||
| AGE/RAGE pathway | |||||
| Signaling by Insulin receptor | |||||
| Folate Metabolism | |||||
| Type II diabetes mellitus | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | Clinical pipeline report, company report or official report of Boehringer Ingelheim Pharmaceuticals. | ||||
| REF 2 | Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol. 2004 Jun 1;67(11):2081-91. | ||||
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