Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09NBM
|
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| Former ID |
DIB007427
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| Drug Name |
SB-435495
|
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| Indication | Arteriosclerosis [ICD9: 440; ICD10:I70] | Discontinued in Phase 1 | [1] | ||
| Company |
GlaxoSmithKline plc
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
n1(c(nc(=O)c(c1)Cc1cnn(c1)C)SCc1ccc(cc1)F)CC(=O)N(Cc1cc<br />c(cc1)c1ccc(cc1)C(F)(F)F)CCN(CC)CC
|
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| Target and Pathway | |||||
| Target(s) | Phospholipase A2 | Target Info | Inhibitor | [2] | |
| BioCyc Pathway | Phospholipases | ||||
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Ether lipid metabolism | |||||
| Arachidonic acid metabolism | |||||
| Linoleic acid metabolism | |||||
| alpha-Linolenic acid metabolism | |||||
| Metabolic pathways | |||||
| Ras signaling pathway | |||||
| Vascular smooth muscle contraction | |||||
| Pancreatic secretion | |||||
| Fat digestion and absorption | |||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | ||||
| Reactome | Acyl chain remodelling of PC | ||||
| Acyl chain remodelling of PE | |||||
| Acyl chain remodelling of PI | |||||
| WikiPathways | Glycerophospholipid biosynthesis | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015443) | ||||
| REF 2 | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. Respir Res. 2012 Nov 12;13:100. | ||||
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