Drug Information

Drug General Information
Drug ID
D09KXA
Former ID
DIB011605
Drug Name
PD-131112
Synonyms
CI-990; [S-(R*,R*)]-7-[3-(2-Aminopropanamido)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; (S,S)-7-[3-(Alanylamino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 122536-20-3
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Discontinued in Phase 1 [544944]
Structure
Download
2D MOL

3D MOL
Formula
C16H17FN4O3
Canonical SMILES
C1CC1N2C=C(C(=O)C3=CC(=C(N=C32)N4CCC(C4)N)F)C(=O)O
InChI
1S/C16H17FN4O3/c17-12-5-10-13(22)11(16(23)24)7-21(9-1-2-9)14(10)19-15(12)20-4-3-8(18)6-20/h5,7-9H,1-4,6,18H2,(H,23,24)/t8-/m0/s1
InChIKey
MUKSDTOOLRNSIO-QMMMGPOBSA-N
CAS Number
CAS 122536-20-3
PubChem Compound ID
72448
PubChem Substance ID
602968, 8195198, 14899878, 43128612, 50420756, 57318725, 103095338, 103148759, 103234155, 104352972, 117510534, 128649336, 135029183, 163304301, 235200706
Target and Pathway
Target(s) Bacterial DNA gyrase Target Info Modulator [1572591]
References
Ref 544944Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001614)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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