| Drug General Information |
| Drug ID |
D09KKU
|
| Former ID |
DNC000868
|
| Drug Name |
Lefaxin
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H13BrN2O2
|
| Canonical SMILES |
C[N+]1=CC=CC(=C1)OC(=O)N(C)C.[Br-]
|
| InChI |
1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
|
| InChIKey |
VNYBTNPBYXSMOO-UHFFFAOYSA-M
|
| CAS Number |
CAS 101-26-8
|
| PubChem Compound ID |
|
| PubChem Substance ID |
518187, 855974, 7847553, 8149951, 8155122, 15197064, 17405593, 24277865, 26612441, 26679847, 26747656, 26747657, 29226381, 48416499, 48424020, 49854543, 50106936, 50106937, 53778141, 53790209, 56422100, 57324314, 78628951, 85089050, 85174466, 87575426, 91011577, 92124809, 92303343, 92307824, 99301295, 103213502, 104170079, 104253248, 104315283, 117370119, 118047400, 118816708, 121362055, 121362581, 124638120, 124757370, 124800762, 125164174, 125336570, 126617391, 126659958, 126664369, 134340174, 134340399
|
| Target and Pathway |
| Target(s) |
Coagulation factor Xa |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Complement and coagulation cascades
|
|
PANTHER Pathway
|
Blood coagulation
|
|
Pathway Interaction Database
|
Beta2 integrin cell surface interactions
|
|
PathWhiz Pathway
|
Coagulation
|
|
Reactome
|
Extrinsic Pathway of Fibrin Clot Formation
|
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Intrinsic Pathway of Fibrin Clot Formation
|
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Common Pathway of Fibrin Clot Formation
|
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Gamma-carboxylation of protein precursors
|
|
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
|
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
|
|
WikiPathways
|
Complement and Coagulation Cascades
|
|
Human Complement System
|
|
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
|
|
Blood Clotting Cascade
|
|
Formation of Fibrin Clot (Clotting Cascade)
|
| References |
| REF 1 | Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. |
|---|
